Translational metabolomics in cancer research
نویسندگان
چکیده
منابع مشابه
Integrative Analysis Workflow for Untargeted Metabolomics in Translational Research
The cancer metabolome may be the most studied to date, particularly in the area of breast cancer diagnostics [1]. Several breast cancer studies using multivariate analysis of metabolite profiles from tissue have shown very high sensitivity and specificity in discriminating a malignant phenotype from benign tissue, and even cancer grade and hormone status [3-5]. Numerous studies have also indica...
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1 Purpose: Metabolomics depicts metabolic changes in biological systems using a 2 multiparametric analysis technique. This study assessed the metabolomic profiles of 3 serum, obtained by proton NMR spectroscopy, from cirrhotic patients with and without 4 hepatocellular carcinoma (HCC). Experimental Design: The study included 154 5 consecutive patients with compensated biopsy-proven alcoholic ci...
متن کاملTranslational research in breast cancer.
Translational research (TR) involves both the development of novel diagnostics and novel therapeutics. These two major developmental areas are often associated with each other and these associations often bring new paradigms in the management of cancer patients. For example, the development of trastuzumab-based treatments has been conducted in harmony with the development of new methodologies t...
متن کاملTranslational research in breast cancer.
routine. This also explains the interest of a larger public in these issues; breast cancer activists are willing to take up a role in the creation of biological and clinical databases. Patients are asked to lobby for and help in clinical studies. On the other hand, the access to human tissues is only possible via the patient. The discussion around the Human Tissue Act in Britain may serve as on...
متن کاملTranslational Research in Pancreatic Cancer
169: KRAS mutations in a population of patients operated for pancreatic adenocarcinoma [5] Researchers from Denmark presented a translational study on KRAS mutations in early pancreatic cancer. Previous reports had showed that the frequency of KRAS gene mutations in pancreatic cancer was as high as 75-90% [2]. This high percentage of KRAS mutations was representative of all pancreatic cancer st...
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ژورنال
عنوان ژورنال: Biomarkers in Medicine
سال: 2015
ISSN: 1752-0363,1752-0371
DOI: 10.2217/bmm.15.52